Sperm stem cells

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Author: Chris Palmer. A new study led by researchers at University of Utah Health tracing the development of human sperm stem cells to mature sperm cells has yielded the most comprehensive view of this process to date. The results, published in the journal Cell Stem Cell , expand the understanding of human testis development and point to potential treatments for male infertility. Spermatogenesis—the production of sperm cells—involves the differentiation of spermatogonial stem cells into mature sperm through a complex process.
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Cell Science

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How Close Are We To Making Babies from Bone Marrow? | Discover Magazine

In , a group of researchers reported a startling discovery: They had created sperm-like cells out of stem cells taken from the bone marrow of human men. Two years later, however, the study was retracted due to charges of plagiarism. Thirteen years later, the ability to create functional human sperm out of stem cells remains elusive. Scientists have been trying to figure out how to create functioning human gametes — eggs and sperm — from stem cells for 20 or 30 years, says Vittorio Sebastiano , a stem cell biologist at Stanford University whose research focuses on reproductive biology. Doing so would help people struggling with infertility have children and help scientists unlock the secrets of human development. Since , scientists have made considerable progress on this front, creating healthy mouse pups from stem cell-generated gametes and even immature human egg cells.
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Preserving sperm stem cells restores fertility in mice

Infertility affects one in seven men of reproductive age worldwide. One idea for treating male sterility is spermatogonial stem cell SSC therapy. In this approach, sperm stem cells in the testis are transferred to a test tube, cultured and nudged into becoming fully fledged sperm. However, a key bottleneck has been identifying just the right conditions to get human SSCs to grow in the lab.
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